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黃麗華 Lih-Hwa Hwang

發佈日期 : 2016-03-16

Updated: 2019/01

National Yang-Ming University

 

NAME

Hwang, Lih-Hwa (黃麗華)

POSITION TITLE/AFFILIATIONS

Professor/ Institute of Microbiology and Immunology

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

National Taiwan University, Taiwan

B.S.

1974-1978

Microbiology

Princeton University, USA

Ph.D.

1980-1985

Molecular Virology (Mentor: Eli Gilboa)

 

A.   Current Research 

1.    First, I am interested in the regulation of RIG-I-like receptor (RLR) signaling which leads to interferon (IFN) production upon viral infection.  IFN response plays the first line of host defenses against pathogens and is one of the important innate immune responses.  Aiming to identify novel molecules participating in the regulation of RLR signaling pathway, we have used a shRNA screening strategy to search for novel molecules involved in IFN synthesis.  One important molecule, PIM1, was identified among others. The underlying mechanisms of PIM1 in regulating RLR signaling are currently being investigated.   

 

2.   Second, my lab is also studying the molecular virology of enterovirus 71.  We have searched for cellular factors important for EV71 viral replication.  HSC70 is one of the factors we have identified, which seems to play a positive role in EV71 replication cycle.  In addition, several other members of the HSP70s family are also involved. We are now investigating the mechanisms by which these HSP70s function to regulate the EV71 life cycle. 

 

3.   Third, we have employed hydrodynamic injection method to establish an HBV replication system in FVB mice.  The system is unique in that the HBV DNA persistently replicates in the mouse livers for up to 1 year and produces only mild inflammation, which is in sharp contrast to the severe inflammation and rapid viral clearance observed in BALB/c or C57BL/6 mice.  This system will allow us to investigate the pathogenesis and the persistence mechanisms associated with HBV replication and to develop therapeutic strategies for the treatment of chronic hepatitis B.

 

B.   Positions and Honors

Positions and Employment

2008.05 - Present

Professor of the Institute of Microbiology and Immunology, National Yang-Ming University

2010.09 – 2017.01

Director of the Institute of Microbiology and Immunology, National Yang-Ming University

1991.08 - 2008.04

Senior Research Fellow of the Hepatitis Research Center, National Taiwan University Hospital

1989.08 - 2013.07

Adjunct Professor of the Graduate Institute of Microbiology, College of Medicine, National Taiwan University

1986.11 - 1991.07

Senior Research Fellow of the Division of Molecular Biology, Development Center for Biotechnology

1990.01 - 1991.12

Associate Director of the Division of Molecular Biology, Development Center for Biotechnology

1987.08 - 1988.07

Adjunct Associate Professor of the Institute of Microbiology and Immunology, National Yang-Ming University

1985.01 - 1986.10

Post-Doctoral Fellow of the Wistar Institute , Philadelphia

 

Honor, Prizes, Awards

1997                      Ching-Shin Medical Award, National Taiwan University

1999-2000             Outstanding Award, National Science Council

2009-2011             Excellent research award, National Yang-Ming University

2011-2013             Excellent research award, National Yang-Ming University

2013                      Excellent teachers, School of Life Science, National Yang-Ming University 

2016                      Outstanding teachers, National Yang-Ming University

2017                      Excellent teachers, Department of Medicine, National Yang-Ming University 

 

C.   Selected Publications in the past 5 years

  1. Lin, H.C., Huang, Y.T., Yang, Y.Y., Lee, P.C., Hwang, L.H., Lee, W.P., Kuo, Y.J., Lee, K.C., Hsieh, Y.C., Liu, R.S.. (2014).  Beneficial effects of dual vascular endothelial growth factor receptor/fibroblast growth factor receptor inhibitor brivanib alaninate in cirrhotic portal hypertensive rats.  J. Gastroenterol. Hepatol. 29: 1073-1082.
  2. Chen, G.A., Lin, Y.R., Chung, H.T., and Hwang, L.H.* (2017). H-Ras exerts opposing effects on type I interferon responses depending on its activation status.  Front. Immunol. 8: 972.
  3. Su, Y.S., Tsai, A.H., Ho, Y.F., Huang, S.Y., Liu, Y.C., and Hwang, L.H.* (2018). Stimulation of the internal ribosome entry site (IRES)-dependent translation of enterovirus 71 by DDX3X RNA helicase and viral 2A and 3C proteases. Front. Microbiol. 9: 1324.
  4. Lin, C.T., Hsieh, Y.T., Yang, Y.J., Chen, S.H., Wu, C.H., and Hwang, L.H.* (2019). B-cell lymphoma 6 (BCL6) is a host restriction factor that can suppress HBV gene expression and modulate immune responses. Front. Microbiol. 9: 3253.

* Corresponding author

 

D.  Research Grant Support

  1. Ministry of Science and Technology Grant, MOST 103-2320-B-010-020-MY3, Lih-Hwa Hwang

       2014/08/01-2018/07/31
Investigation of the innate immune responses in persistent hepatitis B viral replication

       Role : PI

  1. Ministry of Science and Technology Grant, MOST 104-2321-B-010-015, Lih-Hwa Hwang

       2015/01/01-2017/12/31
Investigation of the protein complexes and the mechanisms involved in enteroviral IRES-mediated translation

       Role : PI

  1. National Health Research Institute Grant, NHRI-EX104-10255SI, Lih-Hwa Hwang

       2013/01/01-2015/12/31
Investigating the mechanisms for the regulation of RLR signaling pathway by OTUB2 and PIM1

       Role : PI

 

E.   Patent and Technology Transfer

中華民國專利 I 359030, Lih-Hwa Hwang

2012/03 - 2027/08

治療細胞增生異常之方法與組合物

Role : PI

 

 

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