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呂春敏 Chuen-Miin Leu

Updated: 2015/9/16

National Yang-Ming University

                 

NAME

Chuen-Miin Leu

POSITION TITLE/AFFILIATIONS

Associate professor, Institute of Microbiology and Immunolgy, National Yang-Ming University

EDUCATION/TRAINING

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Institute of Microbiology and Immunology, National Yang-Ming University

PhD

1994-2000

Cancer biology

Institute of Microbiology and Immunology, National Yang-Ming University

M. S.

1992-1994

Cancer biology

Department of Zoology, National Taiwan University

B. S.

1988-1992

Zoology

A.   Current Research (Maximum 500 words)

B cell activation is the first step of the humoral response. After encounter cognate antigens, B cells undergo activation, proliferation, and then differentiation to become memory or plasma cells. In addition to fighting against infection, B cells play an important role in the pathogenesis of many autoimmune diseases. We are interesting in identifying novel molecules in the regulation of B cell activation and humoral response. We discovered that Decoy receptor 3 (DcR3, a soluble member in the TNF receptor family) suppressed B cell proliferation and antibody secretion. Using a DcR3 transgenic mouse model, we found that DcR3 reduced humoral response in vivo. DcR3 may bind novel receptors on B cells, and reduced NF-kB activation and antibody secretion. Furthermore, we found that DcR3 level in synovial fluid from rheumatoid arthritis patients negatively correlated to serum red blood cell sedimentation rate and DAS28 clinical severity scores. These results suggest that DcR3 may be able to suppress inflammation in humans.

B.   Positions and Honors.

Positions and Employment

2005~2014 Assistant professor, Institute of Microbiology and Immunology, National Yang-Ming University

2001~2004 Postdoctoral fellow, Division of Developmental & Clinical Immunology, Department of Medicine, University of Alabama at Birmingham, USA

2000~2001 Postdoctoral fellow, Department of Medical Research and Education, Veterans General Hospital, Taipie

C.   Selected Publications in the past 5 years (2010.08.01~2015.09.30)

1. C. M. Leu, Y. C. Lu, W. L. Peng, H. T. Chu, and C. Hu. The hepatitis B virus e antigen suppresses the respiratory burst and mobility of human monocytes and neutrophils. Immunobiology 2014; 219:880-887. (: co-corresponding author) (2012 SCI, IF: 2.814;Rank: 51.09%, Immunology)

2. M. H. Chen, P. C. Liu, C. W. Chang, Y. A. Chen, M. H. Chen, C. Y. Liu, C. M. Leu, and H. Y. Lin. Decoy receptor 3 suppresses B cell functions and has a negative correlation with disease activity in rheumatoid arthritis. Clin. Exp. Rheumatol. 32: 715-723. (: co-corresponding author) (2012 SCI IF: 2.655;Rank: 48.28%, Rheumatology)

3. C. M. Leu. Nck, a missing adaptor between B cell receptor complex and BCAP/PI3K/Akt pathway. Cellular & Molecular Immunology 2014; 11(2):120-2 (single author) (2012 SCI IF: 3.419;Rank: 37.23%, Immunology)

4. Z. M. Huang, J. K. Kang, C. Y. Chen, T. H. Tseng, C. W. Chang, Y. C. Chang, S. K. Tai, S. L. Hsieh and C. M. Leu. Decoy receptor 3 suppresses TLR2-mediated B cell activation by targeting NF-kB. Journal of Immunology 2012; 188:5867-5876 (: corresponding author) (2012 SCI IF: 5.52;Rank: 17.52%, Immunology)

5. S. J. Lin, M. Lo, R. L. Kuo, S. R. Shih, D. M. Ojcius, J. Lu, C. K. Lee, H. C. Chen, M. Lin M, C. M. Leu, C. N. Lin and C. H. Tsai.. The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection. Journal of Biomedical Science 2014; 21:99 (2013 SCI IF: 2.74)

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