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徐嘉琳 Chia-Lin Hsu

 

 

 

 

 

BIOGRAPHICAL SKETCH

Chia-Lin Hsu

clhsu@nycu.edu.tw,Chialin.hsu66@gmail.com, chialin.hsu@ym.edu.tw

+886-939-583-986

 

NAME

 

Chia-Lin Hsu

POSITION TITLE

 

Associate Professor

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

National Taiwan University, Taipei, Taiwan

B.S.

1999

Zoology

National Yang-Ming University, Taipei, Taiwan

M.S.

2001

Microbiology and Immunology

Duke University, Durham, NC, U.S.A.

Ph.D.

2007

Immunology

Genentech, South San Francisco, CA, U.S.A.

Postdoc

2012

Immunology

         
 
  • Personal Statement:

 

Trained as an immunologist, understanding how complicated and effective our immune system is, has always been an endless pursuit. The immune system needs to develop and mature properly, recognize foreign insult, and initiate the proper inflammatory response to mount an effective response to fight off the pathogens. Once the threat is removed, it enters the resolution phase to regain homeostasis. Dysregulation of any of these steps leads to the development of diseases. Activation of immune response is an energy-consuming event since active transcription, rapid production of proteins, and cell proliferation are all crucial parts of the inflammatory response. In meeting the metabolic demand and efficient recycling of metabolites, metabolite transporters have a central role in redistributing essential biomolecules in and out of the cell. My research interest is to understand how these metabolite transporters respond to and facilitate the development and activation of the immune system during homeostatic or disease settings.

          Having extensive experience in both academic and industry settings have enabled me to gain valuable insights into the challenges each side faces. Mentoring young minds to ask key questions and support them to build up confidence and independence is a delight that comes with my position at academic; at the same time, it is also a personal goal to apply my experience in industry to bridge basic research findings to the development of translational products.

 

  • Positions:

 

2019-present: Associate Professor

2013-2019: Assistant Professor

Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan

2012-2013: Senior Scientist

Center of Therapeutic Innovation, Pfizer, San Francisco, California, U.S.A.

 

  • Selected peer-reviewed publications (in chronological order):
  • Fan HH, Tsai TL, Dzhagalov I, Hsu CL*. Evaluation of Mitochondria Content and Function in Live Cells by Multi-color Flow Cytometric Analysis. Methods in Molecular Biology, 2021, Vol. 2276: 203-213. doi: 0.1007/978-1-0716-1266-8_15  *corresponding author
  • Hsuan-Po Hsu, Yun-Tzu Chen, Yu-Ying Chen, Chih-Yu Lin, Po-Yu Chen, Shio-Yi Liao, Ciara Christianne Y. Lim, Yu Yamaguchi, Chia-Lin Hsu, Ivan L. Dzhagalov. Heparan sulfate is essential for thymus growth. Journal of Biological Chemistry, Feb, 2021, S0021-9258(21)00192-7, https://doi.org/10.1016/j.jbc.2021.100419

 

  • Feng HK, CF Chu, Sun KH, Hsu CL, Dzhagalov I. Examination of Fas-induced apoptosis of murine thymocytes in thymic tissue slices reveals that Fas is dispensable for negative selection. Front. Cell Dev. Biol., 21 October 2020 | https://doi.org/10.3389/fcell.2020.586807

 

  • Hsu KH, Wei CW, Su YR, Chou T, Lin YL, Yang FC, Tsou AP, Hsu CL, Tseng PH, Chen NJ, Jeng KS, Leu CM. Upregulation of RelB in the miR-122 knockout mice contributes to increased levels of proinflammatory chemokines/cytokines in the liver and macrophages. Immunology Letters, July 02, 2020

 

  • Zhou TA, Hsu CL, Dzhagalov IL*. Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices. Methods Mol Biol. 2020;2111:205-219. doi: 10.1007/978-1-0716-0266-9_17.

 

  • Hsu CL*, Dzhagalov I. Metabolite Transporters—The Gatekeepers for T cell Metabolism. Immunometabolism. 2019;1:e190012. doi.org/10.20900/immunometab20190012 *corresponding author

 

  • Hsu CL*, Dzhagalov I, Niu DM*. “Response to Chung et al.” Genetics in Medicine Jan 22, 2019 * co-corresponding author

 

  • Wei, C.W., Zhou, T.A., Dzhagalov, I.L., Hsu, C.L.* Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells. J. Vis. Exp. e58844, doi:10.3791/58844 (2018). *corresponding author

 

  • Wei CW, Lee CY, Lee DJ, Chu CF, Wang JC, Wang TC, Jane WN, Chang ZF, Leu CM, Dzhagalov I, Hsu CL*. Equilibrative Nucleoside Transporter 3 regulates T cell homeostasis by coordinating lysosomal function with nucleoside availability. Cell Reports 23, 2018: 2330-2341. doi:10.1016/j.celrep.2018.04.077  *corresponding author

 

  • Hsu MJ, Chang FP, Lu YH, Hung SC, Wang YC, Yang AH, Lee HR, Sung SH, Wang YF, Yu WC, Hsu TR, Huang, Chang SK, Dzhagalov I, Hsu CL*, Niu DM*. Identification of Lysosomal and Extralysosomal Globotriaosylceramide (Gb3) Accumulations Before the Occurrence of Typical Pathological Changes in the Endomyocardial Biopsies of Fabry Disease Patients. Genetics in Medicine 06 June 2018: 21, 224-232 doi:10.1038/s41436-018-0010-z * co-corresponding author

 

  • Hsu MJ, Hsiao W, Chang FP, Ding HT, Lu YH, Chang SK, Dzhagalov I, Niu DM, Hsu CL*. Pathogenic T cells contribute to the later-onset (IVS4+919G>A) Fabry Disease cardiomyopathy (submitted) *corresponding author

 

  • Chuang TY, Cheng AJ, Lan TY, Huang IH, Shiau CW, Hsu CL, Liu YW, Tseng PH, Chang ZF, Kuo JC. Suppression of LPS-induced inflammatory responses by the hydroxyl groups of dexamethasone. Oncotarget 2017 Jul 25;8(30):49735-49748

 

  • Hsu TR, Hung SC, Chang FP, Yu WC, Sung SH, Hsu CL, Dzhagalov I, Yang CF, Chu TH, Lee HJ, Lu YH, Chang SK, Liao HC, Lin HY, Liao TC, Lee PC, Li HY, Yang AH, Ho HC, Chiang CC, Lin CY, Desnick RJ, Niu DM. Later Onset Fabry Disease, Cardiac Damage Progress in Silence, Journal of the American College of Cardiology 68, 2016: 2554-2563.
  • Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP, Park H, Xu M, Sun M, Rangell L, Lutman JL, Ulufatu S, Stefanich E, Chalouni C, Sagolla M, Diehl L, Fielder P, Dean B, Balazs M and Martin F.  Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Macrophage Lysosome Functions and Homeostasis. Science, 6 January 2012: 89-92.

 

  • Chung E, Hsu CL, and Kondo M. Constitutive MAP kinase activation in hematopoietic stem cells induces myelo-proliferative neoplasm.  PLos One, 2011;6(12):e28350. Epub 2011 Dec 2.

 

  • Hsu CL, and Kondo M.To be or not to be: that is the question—Lineage Commitment in Hematopoiesis.  Current Immunology Reviews, 2007 Nov:3 (4) pp. 258-268(11)

 

  • Hsu CL, Kikuchi K, Kondo M. Activation of MEK/ERK signaling is involved in myeloid lineage commitment during hematopoiesis.  Blood, 2007 Sep 1;110(5):1420-8. Epub 2007 May 29.

 

  • Hsu CL, King-Fleischman AG, Lai AY, Matsumoto Y, Weissman IL, Kondo M. Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors.  Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):672-7.

 

  • Kikuchi K, Lai AY, Hsu CL, Kondo M. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF.  J Exp Med. 2005 Apr 18;201(8):1197-203.

 

  • He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, Guo J, Forbush KA, Bevan MJ. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.  Nat Immunol. 2004 Jan;5(1):88-97.

 

D. Research Funding:

 

Outstanding Young Investigator Awards 優秀年輕學者研究計畫

Ministry of Science and Technology (MOST), Taiwan

Investigate the regulatory role of Equilibrative Nucleoside Transporter 3 in infection and inflammation

2019/08/01-2022/07/31

 

Research Grant 整合型研究計畫

Ministry of Science and Technology (MOST), Taiwan

Investigate the role of ENT3 in microglia and its implication in the neuro-inflammation of Huntington Disease

2018/08/01~2021/07/31

 

Outstanding Young Investigator Awards優秀年輕學者研究計畫

Ministry of Science and Technology (MOST), Taiwan

The immunometabolism between T cell activation and the control of nucleoside availability

2015/08/01~2019/07/31

 

Yen Tjing Ling Medical Foundation嚴慶齡基金會研究計畫

Investigate the molecular mechanism of how nucleoside metabolism affects the function of macrophages

2018/01/01~2018/12/31

 

Yen Tjing Ling Medical Foundation嚴慶齡基金會研究計畫

Investigate if nucleoside metabolism plays a role in the differentiation and function of macrophages

2017/01/01~2017/12/31

 

Veterans General Hospitals and University System of Taiwan Joint Research Program榮台聯大研究計畫

Investigate the immune cell functional abnormalities in Fabry Disease

2017/01/01~2017/12/31

 

Research Grant 個別型研究計畫

Ministry of Science and Technology (MOST), Taiwan

Effects of disturbed glycosphingolipid metabolism on immune regulation

2015/08/01~2016/07/31

 

Veterans General Hospitals and University System of Taiwan Joint Research Program榮台聯大研究計畫

Investigate the immune regulation in IVS4 Fabry disease patients

2016/01/01~2016/12/31

 

New Investigator Research Grant 新進人員研究計畫

Ministry of Science and Technology (MOST), Taiwan

The role of the nucleoside transporter ENT3 in T cell development and metabolism

2014/01/01~2015/07/31

 

Member of Research Center

     Cancer Progression Research Center (腫瘤卓越研究中心), NYMU: 2019- Present

     Covid 19 防疫中心, NYMU: 2020-Present

    

  1.  Invited talks:

 

2014/04/28

The 4th Cross straight immunology conference

2014/10/16

2014 NHRI/IBMS Joint International Conference on Inflammation & Disease

2014/11/10

2014 UCSD-NYMU-NCTU Bilateral Symposium

2015/08/21

MacKay Memorial Hospital

2015/08/20

Institute of Biological Chemistry, Academia Sinica

2015/10/11

Graduate Institute of Immunology, National Taiwan University

2015/12/09

2015 Glycoscience Symposium

2015/10/13

The therapeutic advances in Fabry Disease

2015/06/13

Future perspectives for Fabry Disease

2015/03/11

Taiwan and Japan Bilateral Fabry Disease Symposium

2015/10/25

EITA-EITC 2015

2016/03/11

Dep. of Life Science, National Taiwan University

2016/09/05

2016-2017 speaker series Taipei American School

2016/06/13

Current and New prospect of Fabry Disease

2016/06/18

2016 VGH and UST Joint Research Symposium and Precision Medicine in Fabry Conference

2017/06/10

2017 VGH and UST Joint Research Symposium

2018/05/26

2018 Medical camp for high school students

2018/06/01

Graduate Institute of Biomedical Science, Chang Gung University

2018/10/14

The 7th Cross straight immunology conference

2018/10/28

2018 Chinese Society of immunology conference

2019/03/03

Gordon Research Conference: Lysosomal Diseases

2019/07/17

2019 BD Flow User Club Annual Meeting

2019/09/02

Dept. Medical Research, Veteran’s General Hospital, Taipei

     2019/11/12   

 

TBD

Institute of Molecular Genetics, NHRI        

2020 Hong Kong Society of Flow Cytometry Annual Scientific Meeting

(postponed due to COVID-19)

     2020/11/23

Dep. of Pharmacology, National Taiwan University

 

  1. Awards:

 

  • 2019-2021 Outstanding research award 教師研究卓越獎勵
  • 2019 Ta-You Wu Memorial Award 吳大猷先生紀念獎
  • 2019 VGH-UST outstanding research award 榮台聯大合作研究優良論文獎
  • 2018 Li-Yang Shen memorial award 沈力揚先生紀念獎
  • 2018 Shui-Te Shen memorial award for excellent immunology research 沈水德優秀論文獎
  • 2018 VGH-UST research symposium poster award 榮台聯大合作研究優良壁報獎
  • 2016 Teaching excellence award, School of life science, NYMU 陽明大學生命科學院優良教師獎

 

 

  1. Offered courses:

 

  • Basic Immunology: Full semester course (Undergraduate level) in Chinese
  • Microbiology and Immunology: Multiple sessions (Graduate level) in Chinese
  • Methodology: Flow cytometry and applications (Graduate level) in Chinese
  • Advanced immunology: Hematopoiesis, Immunometabolism (Graduate level) in Chinese
  • Molecular Cell Biology: Immune system, Stem cells (Graduate level) in English
  • Current techniques in molecular biology: Flow cytometry and applications (Graduate level) in English
  • Current Topics in Immunology: Full semester course (Graduate level) in English
  • Seminars: Full semester course (Graduate level) in English
  • 授課資料表

課  程  名  稱

開課年級

每週時數

修習人數(約)

必/選修

合 授 者

高等微生物及免疫學通論-免疫

碩博

2

25

 必

微免所教師(共四位合授)

現代生物學研究方法

碩博

3

25

 必

微免所教師

高等免疫學

碩博

3

10

 必

微免所教師(共六位合授)

基礎免疫學 (生命科學系)

大三

2

25-50

免疫學新知(全英語授課)

碩博

2

15-20

葛一樊老師

微生物及免疫學專題討論(全英語授課)

2

15-20

微免所教師(共三位合授)

微生物及免疫學專題討論(全英語授課)

2

15-20

微免所教師(共三位合授)

生醫科學技術(全英語授課)

碩博

2

10

生科院教師

 分子生物學(全英語授課)

碩博

2

10

生科院教師

先天免疫力受體及感應器在人類疾病的角色

碩博

2

10

生科、醫學院教師

微生物及免疫學通論-免疫 (護理系)

大二

2

30

微生物及免疫學通論-免疫 (醫學系)

大二

4

100

藥理 (藥學系)

大二

2

30

藥學、生科院教師

 

H. Committee and Administrative activity:

  • Review Editor in Molecular Innate Immunity, Frontiers. 2020-present

 

  • Ad hoc Journal reviewer:

Scientific Reports, Frontiers in immunology, Journal of Microbiology, Immunology and Infection

 

  • Ad hoc Funding reviewer:

            Ministry of Science and Technology, Taiwan

            科技部生科司醫學生化及分子生物組複審委員2019- 2020

            科技部生科司寄生蟲學、醫事技術及實驗診斷學科複審委員: 2021-resent

 

  • NYMU IACUC committee: 2016-2020

 

  • Taiwan International Graduate Program (TIGP) steering committee: 2015- Present

 

  • Institute of Microbiology and Immunology, NYMU

            Graduate Student Admission Committee: 2014- Present

            Graduate Course Curriculum Committee: 2014- 2020

 

  • Organizing Committee 2019 Formosa Immunology Spring School (FISS): Present

 

  • NYMU Student Affair committee: 2016- 2019

 

  • School of Life Science Faculty Representative, NYMU: 2017- 2019, 2020-Present

 

 

 

I. Mentoring activity:

 

  • Ph.D. student: Hsui-Han Fan(2019-Present), Chin-Wen Wei (2014-2019)

 

  • M.S. student: Din-Jin Lee, Wen Hsiao (2015 graduate)

                      Chia-Yin Lee, Chia-Chun Tu, Share-Ler Tay, He-Ting Ding (2016 graduate),

                      Ming-Jia Hsu, Po-Kai Chou (2017 graduate),

                      Ju-Chu Wang, Tien-Chiao Wang (2018 graduate),

                      Hsui-Han Fan, Cheng-Han Tsai (2019 graduate),

                      Tzong-Lin Tsai, Ping-Yu Hung, Yu-Ting Hsieh (2020 graduate)

                      Jian-Wen Heng, Pei-Yuan Tsai, Ying-Sui Lu (2022 graduate)

                      Shen-Yen Huang (2023 graduate)

                      Yu-Chia Huang (2024 graduate)

 

  • B.S. student: Tze-Han Chao (2016), Pham Hong Ha (2017), Jia-Chin Wei (2017), Sze-Huey Leong (2020), Tze-Ling Kuo (2021), Cathy Hsu (2021)

 

  • M.D. student: Hui-Ju Cheng (2024), Shao-Chun Huang (2023), Huan-Yu Wu (2025)

 

  • Summer interns: Monica Lu (Taipei American School, 2014), Stephanie Cheng (Taipei American School, 2015), Martina Kerndl (TIGP-IIP, 2016), Christine Chen (Taipei American School, 2017), Albert Ay (Michigan State University, U.S.A., 2021), Emma Kuok (Taipei American School, 2021)

 

  • 指導學生得獎紀錄:

 

年度

競賽、會議名稱

學生(碩/博)

2021

陽明大學優良研究論文比賽初賽

第一名:呂瑩穗

第三名:蔡沛芫

2020

中華民國免疫學會生醫年會口頭競賽

蔡宗霖(碩)

2020

陽明大學優良研究論文比賽決賽

蔡宗霖(碩)

2020

陽明大學優良研究論文比賽初賽

第一名:蔡宗霖(碩)

第三名:洪秉煜(碩)

佳作: 謝毓庭(碩)

2019

Formosa Immunology Spring School 2019

碩士班入選參與學者:蔡宗霖、謝毓庭

2019

Gordon conference: Phagocytes

壁報入選口頭報告:

范琇涵(碩)

2019

尹珣若論文比賽初賽

第一名:范琇涵(碩)

2018

學術交流競賽

第二名:魏晉文(博)

2017

尹珣若論文比賽初賽

佳作:王恬喬同學

2016

尹珣若論文比賽初賽

佳作:徐明嘉同學

2016

罕見疾病基金會研究論文獎

徐明嘉

2016

生命科學系大學部專題壁報展

優等獎 趙姿涵

2015

尹珣若論文比賽初賽

佳作:李佳螢同學

佳作:涂嘉峻同學

2015

罕見疾病基金會研究論文獎

丁鶴婷

2014

罕見疾病基金會研究論文獎

蕭雯

 

 

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