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蔡雨寰 Yu-Huan Tsai

Education:
 
2010-2014
Ph.D, B3MI doctoral school, University Paris 7, France.
(Pasteur-Paris University International doctoral program)
Institut Pasteur, Biology of infection unit, INSERM U1117
 
2006-2008
M.Sc., Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
 
2002-2006
B.Sc., Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan
 
 
Experience:
 
2017-present
Postdoctoral research scholar (MOST), Laboratory of Human Immunology and Infectious Diseases Graduate Institute of Clinical Medical Sciences, Chang-Gung University, Taoyuan, Taiwan
 
2015-2017
Postdoctoral fellow, Department of Medical Biotechnology and Laboratory Science, Chang-Gung University, Taoyuan, Taiwan
 
2014
07-12
Postdoctoral fellow, Institut Pasteur, Biology of infection unit, INSERM U1117, Paris, France
 
2010-2014
PhD student, Institut Pasteur, Biology of infection unit, INSERM U1117, Paris, France
 
2009-2010
Research assistant, Department of Medical Biotechnology and Laboratory Science, Chang-Gung University, Taoyuan, Taiwan
 
 
Journal editor:
International Journal of Microbiology, 2015
Guest Editor  
 
International collaboration:
Listeria biodiversity and pathognesis 
Marc Lecuit (MD, PhD)  Institut Pasteur, Biology of infection unit, INSERM U1117, Paris, France
 
Invited seminar (in 5 years):
Oct. 19, 2017        2017 Research and diagnosis center, Taiwan CDC
 
Aug. 4, 2017         2017 Taiwan Yeast Meeting, Taiwan
 
Aug. 19, 2016       2016 Taiwan Yeast Meeting, Taiwan
 
Aug. 17, 2016       The 21st Conference on Bacteriology, Taiwan
 
June 20, 2016       Institute of Biomedical Science, Academia Sinica, Taiwan
 
Oct.  23, 2015     Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taiwan
 
Jan. 6, 2015      Department of Medical Biotechnology and Laboratory Science, Chang-Gung University, Taiwan
 
 
 
Journal papers:
  1. Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, Wu TR, Tsai YH, Yeh TS, Lu JJ, Lai HC, and Young JD. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes. (Lond) 2018 Feb;42(2):231-243
     
  2. Wei CF*, Tsai YH*, Tsai SH, Lin CS, Chang CJ, Lu CC, Huang HC, Lai HC. Cross-talk between bacterial two-component systems drives stepwise regulation of flagellar biosynthesis in swarming development. Biochem Biophys Res Commun. 2017 Jul 15;489(1):70-75 *co-first author
     
  3. Lin CS*, Tsai YH*, Chen CC, Chang WW, Lin YC, Chang CJ, Tseng SF, Wu TR, Lu CC, Horng JT, Martel J, Ojcius DM, Young JD, Lai HC. An iron detection system determines bacterial swarming initiation and biofilm formation. Sci Rep. 2016 Nov 15;6:36747 *co-first author
     
  4. Maury MM*, Tsai YH*, Charlier C, Touchon M, Chenal-Francisque V, Leclercq A, Criscuolo A, Gaultier C, Rousse S, Brisabois A, Disson O, Rocha EP, Brisse S, Lecuit M. Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity. Nat Genet. 2016 Mar 48(3)308-13 *co-first author
     
  5. Gessain G, Tsai YH, Travier L, Bonazzi M, Grayo S, Cossart P, Charlier C, Disson O, Lecuit M. PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes. J Exp Med. 2015 Feb 9;212(2):165-83.
     
  6. Tsai YH, Disson O, Bierne H, Lecuit M. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses. PLoS Pathog 2013;9(5):e1003381
     
  7. Lai HC, Chang CJ, Yang CH, Hsu YJ, Chen CC, Lin CS, Tsai YH, Huang TT, Ojcius DM, Tsai YH, Lu CC. Activation of NK cell cytotoxicity by the natural compound 2,3-butanediol. J Leukoc Biol. 2012 Oct;92(4):807-14
     
  8. Tsai YH, Wei JR, Lin CS, Chen PH, Huang S, Lin YC, Wei CF, Lu CC, Lai HC. RssAB signaling coordinates early development of surface multicellularity in Serratia marcescens. PLoS ONE 2011;6(8):e24154
     
  9. Lin CS, Horng JT, Yang CH, Tsai YH, Su LH, Wei CF, Chen CC, Hsieh SC, Lu CC, Lai HC. RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens. Infect Immun. 2010 Nov;78(11):4870-81
     
  10. Hsieh SC, Lu CC, Horng YT, Soo PC, Chang YL, Tsai YH, Lin CS, Lai HC. The bacterial metabolite 2,3-butanediol ameliorates endotoxin-induced acute lung injury in rats. Microbes Infect. 2007 Oct;9(12-13):1402-9
     
  11. Soo PC, Horng YT, Lai MJ, Wei JR, Hsieh SC, Chang YL, Tsai YH, Lai HC. Pirin regulates pyruvate catabolism by interacting with the pyruvate dehydrogenase E1 subunit and modulating pyruvate dehydrogenase activity. J Bacteriol. 2007 Jan;189(1):109-18
     
  12. Wei JR, Soo PC, Horng YT, Hsieh SC, Tsai YH, Swift S, Withers H, Williams P, Lai HC. Regulatory roles of spnT, a novel gene located within transposon TnTIR. Biochem Biophys Res Commun. 2006 Sep 29;348(3):1038-46
     
  13. Wei JR, Tsai YH, Horng YT, Soo PC, Hsieh SC, Hsueh PR, Horng JT, Williams P, Lai HC. A mobile quorum-sensing system in Serratia marcescens. J Bacteriol. 2006 Feb;188(4):1518-25
     
  14. Wei JR, Tsai YH, Soo PC, Horng YT, Hsieh SC, Ho SW, Lai HC. Biochemical characterization of RssA-RssB, a two-component signal transduction system regulating swarming behavior in Serratia marcescens. J Bacteriol. 2005 Aug;187(16):5683-90
 
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